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It has a predicted N-terminal mitochondrial targeting motif and a significant proportion has been localised to both the inner and outer mitochondrial membranes [5], [19], [21]

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RNA sequencing and RNAPII-ChIP-Seq analyses demonstrate triptolide's biphasic impact on gene expression in pancreatic cancer (MIA PaCa-2) cells and cancer-associated fibroblasts, highlighting transcriptional down-regulation and specific alterations in histone acetylation [1020, 1021]