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An important future question is in which organismic context FBPs signalling role is most relevant

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The accumulation of amphetamines effectively reverses the transporter carrier mechanisms, leading to a massive, non-exocytotic efflux of vesicular dopamine out into the cytosol, where it is subsequently transported into the synaptic cleft (Wimalasena 2011)(see Figure 2 Mechanism B)

Andrographolide protects against endothelial dysfunction and inflammatory response in rats with coronary heart disease by regulating PPAR and NF-B signaling pathways