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In the cytosol/nucleus, SOD1, Prx1/2, GPx1/4 and the Grx/Trx1 systems, supported by abundant GSH, confine ROS and tune thiol switches on enzymes and transcriptional regulators while DNA repair machineries such as OGG1 and the base-excision repair (BER) pathway continuously survey and correct oxidative lesions, together establishing a compartment-aware redox homeostasis that enables signaling yet limits collateral damage (Le Gal et al

Neuroprotective effects of phenylbutyrate against MPTP neurotoxicity

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