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Herein, we consider the role of GPx1 in maintaining normal physiological functions and protecting against the development and progression of disease (Figure 1)

In a rat model of salt-sensitive hypertension, NAC reduced renal protein loss and tubular damage and improved GFR and renal blood flow, possibly through an enhancement of renal glutathione (Tian 2006)

To protect cells from oxidative damage caused by excessive ROS, plants have evolved antioxidant defense mechanisms that include both enzymatic and non-enzymatic antioxidant systems

Another ferroptosis inducer FIN56, which induces GPX4 protein degradation, also interferes with the FSP1-CoQ10 pathway activation by activating squalene synthase in the mevalonate pathway and thus suppressing CoQ10 activity [44]

Collectively, these research advancements underscore curcumin's robust neuroprotective profile and its potential as a natural, multifaceted therapeutic agent for AD, with ongoing clinical studies focused on optimizing delivery and dosing strategies to overcome bioavailability challenges and maximize clinical benefits

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