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These chronic attributes are generally associated with selective degeneration of dopaminergic neurons, corollary de-pigmentation of substantia nigra pars compacta (SNpc) and concomitant accumulation of -synuclein in insoluble inclusions called Lewy bodies 2,3

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Specifically, quercetin significantly increases the expression of SIRT1, enhances the expression of mitochondrial autophagy signal-related proteins LC3II, PINK1 and Parkin, while reducing the level of p62 to enhance mitochondrial autophagy

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