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A neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors
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For many years, there has been controversy regarding the bioequivalence of different oral levothyroxine products, which had not been reviewed by modern FDA approval processes.1 A controversial study published in Gericke KR

These patients had lower required need of oxygen therapy during hospitalization than did the control group (which did not receive the combination)

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