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Cellular uptake and biological outcomes rely entirely on individual metabolic absorption, existing systemic levels, and overall baseline health

For example, the BCG vaccine when administered via an intravesical route is not actually a vaccine its chemo

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The degree of suppression depends on factors such as the testosterone formulation, the dose, the duration of use, and individual genetic variation in hormone metabolism

Notably, NMDAR-dependent activity has been shown to directly regulate activity-dependent CCK release [55], and NL3 dysfunction disrupts postsynaptic NMDAR localization and NMDAR-dependent synaptic activity [56], potentially perturbing this developmental regulatory process