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This process generates reactive byproducts that require glutathione for detoxification

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Gastroenterology (2008) 5

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demonstrated that combined GHRH + GHRP administration produced 2 to 3 times more GH release than either compound individually in healthy subjects (Anderson et al., J Clin Endocrinol Metab 2001)

Consistently, GSH depletion or silencing of Fe-S cluster-associated GLRXs disrupts mitochondrial redox balance, promotes iron overload, and sensitizes cancer cells to ferroptosis 133,134