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Its recommended to rotate sites to prevent localized irritation
B12 is a water-soluble vitamin essential for neurological function and neurotransmitter regulation, with excess typically excreted in urine

10.1523/JNEUROSCI.12-01-00356.1992 J
Both laboratory and clinical findings in patients with BH 4 deficiencies are attributable to two main pathophysiologic mechanisms: HPA, and depletion of the monoamine neurotransmitters in the central nervous system (CNS)

The Myth of B12 as a Performance Enhancer The Mayo Clinic weighs in definitively on this topic: Some researchers have studied vitamin B-12 to find out if it can raise energy and endurance during exercise
Guidance for industry: Bioavailability and bioequivalence studies for orally administered drug products General considerations
