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PLoS Comput Biol 9(7):e1003120 Kirschner D, Panetta JC (1998) Modeling immunotherapy of the tumorimmune interaction

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Undoubtedly, the members of glutathione transferase family play an important role in metabolism of certain therapeutics, detoxification of environmental carcinogens and reactive intermediates formed from various chemicals by other xenobioticmetabolising enzymes

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have devised hypoxia-responsive sono-activatable semiconducting polymer nanopartners (SPNTi), which are capable of generating singlet oxygen ( 1 O 2 ) during sonodynamic therapy (SDT), thereby disrupting the surface shell to release hypoxia-responsive drugs (tirapazamine (TPZ) conjugates) and MDSC-targeting drug (ibrutinib) (115)

Phosphorylation of YAP results in cytoplasmic localization and degradation, while dephosphorylated YAP proteins translocate to nucleus and induce gene expression through interactions with TEA domain (TEAD) transcription factors