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402,403 Purification and quantitation are performed as outlined above

However, when HSL-deficient mice were produced and shown to efficiently hydrolyze triglycerides the model began to emerge demonstrating ATGL, and not HSL, to be rate-limiting for adipose tissue triglyceride hydrolysis

While elevated plasma concentrations of L-carnitine are associated with increased risk of cardiovascular incidentssuch as heart attack, stroke, and deathindependent of traditional CVD risk factors, this appears to only be true when TMAO is also elevated.6 Proposed mechanisms include effects on cholesterol, the hormone angiotensin IIwhich can raise blood pressure, and increased platelet clumping, possibly leading to blood clots.7.8 A 2020 cross-sectional study using data from 1,653 participants in the Multiethnic Cohort Study identified several associations of plasma levels of TMAO and its precursors, including carnitine, with inflammatory and cardiometabolic biomarkers