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Description

Here, we review the role and function of the GDH pathway in glutamate metabolism and we discuss the additional contributions of the pathway in chromatin regulation, nitrogen catabolite repression, ROS-mediated apoptosis, iron deficiency and sphingolipid-dependent actin cytoskeleton modulation in S.cerevisiae

Potential Side Effects and Risks In human studies, BPC 157 exhibited no significant side effects, indicating a favorable safety profile

Blinding was not performed during animal experiments and data collection, but outcome assessments (e.g., IHC scoring) were conducted by blinded investigators

GDH1-derived AKG directly engages and activates the IKK-NF-B signaling axis, thereby upregulating the expression of the glucose transporter 1 (GLUT1) to promote compensatory glucose uptake and tumor cell survival under low glucose conditions [133]