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Firstly, researchers observed that GHK-Cu increases MMP-2 levels in the conditioned media of cultured dermal fibroblasts, a process not replicated by GHK alone, suggesting that the presence of copper is posited to be necessary for this activity

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The ob/ob and db/db mice exhibited an increase in intestinal permeability and significantly higher plasma endotoxin and proinflammatory cytokines such as IL-1 , IL-6, INF , and TNF- compared to wild-type mice

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