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605 Substantial preclinical evidence supports the neuroprotective effects of GLP-1R agonists on cognition in AD, which is attributed to the ability to reduce A pathology, tau phosphorylation, glial activation, and neuroinflammation

These cognitive improvements are vital, as they address core schizophrenia deficits that affect daily life and overall quality of life (228)

The intestinal microbiota of obese patients is characterized by increased numbers of bacteria of the phylum of Bacteroidetes

In addition, glutathione has a multitude of other vital metabolic functions: it an important cellular reservoir of the sulfur-containing amino acid cysteine, it is a major cell signaling molecule involved in the regulation of apoptosis, cell cycling, and immunity and it participates in active transcellular amino acid transport (4042)

This suggests an extremely wide safety margin, at least in animal models

Research published in Dermatologic Surgery demonstrated that subcutaneous delivery of bioactive peptides produced dermal tissue concentrations 4.2 higher than IM administration at 24 hours post-injection, with sustained elevation lasting 72+ hours