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[DOI] [PubMed] [Google Scholar] 95.Halliwell B

Endothelial dysfunction in pathological processes of chronic liver disease during aging

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Brennan BP, Rauch SL, Jensen JE, Pope HG Jr

M.ChenC

The Nrf2sMAF heterodimer binds to the antioxidant response element (ARE), which leads to the transcription of genes encoding antioxidant and detoxification enzymes such as SOD, CAT, GP X , heme oxygenase 1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), which protect cells from oxidative stress and toxins (124126) (Figure 3)