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While traditional antidepressants are effective, they often have unwanted side effects

In the MEST model, sarcosine administered at doses of 100800 mg/kg (i.p.) demonstrated positive anticonvulsant effects (Socaa et al

Downregulation of CAV1 reduces the levels of GPX4 and FTH1, increases ROS and Fe 2+ concentrations, promotes ferroptosis, and reduces cancer cell migration and invasion, 171 suggesting that the regulatory pathways of CAV1 and ferroptosis may be potential targets for diagnosis and combination therapy strategies in patients with HNSCC

For instance, SSG modulates death receptor signaling (e.g., FAS activation), caspase activity, and antioxidant defense systems (e.g., GPX4 in ferroptosis), as summarized in Table I (31)

The Guardian Nettleton JE, Cho NA, Klancic T, Nicolucci AC, Shearer J, Borgland SL, Johnston LA, Ramay HR, Noye Tuplin E, Chleilat F et al (2020) Maternal low-dose aspartame and stevia consumption with an obesogenic diet alters metabolism, gut microbiota and mesolimbic reward system in rat dams and their offspring

The mTOR pathway is frequently hyperactivated in lung cancer, promoting cell proliferation and metabolic reprogramming