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Tumors are often enriched with immune-suppressive cell-types, such as tumor-associated macrophages (TAMs) or myeloid-derived suppressor cells (MDSCs), and they also may exhibit hypoxic conditions that impede CAR-T cell function [281]

These intracellular stress fibers help to polarize the fibroblast and orient the nucleus in the direction it is traveling

Disclosure of interest: EH is founded by grants from Teggerstiftelsen

Lyophilized NAD+ should be stored at -20C for long-term stability

doi: 10.1007/s11695-018-3371-0