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Because estrogen stimulates the endogenous synthesis of phosphatidylcholine via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, premenopausal women may be less likely to develop signs of choline deficiency in response to a low-choline diet compared to postmenopausal women (18, 19)

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Further evolution of the ACC/AHA Clinical Practice guideline recommendation classification system: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines