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The characteristic dermatological sign of vitamin B 12 deficiency is cutaneous pigmentation, which can be reversed by administration of vitamin B 12 .[4] Increased cutaneous pigmentation is especially accentuated in palmar creases, on the dorsa of hands and feet, in intertriginous areas, on oral mucosa and in recent scars

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Esta formulacin evita los pasos de reconstitucin y facilita una administracin uniforme para estudios regenerativos, vasculares y musculoesquelticos avanzados

AAG-catalyzed excision of the damaged DNA base give rise to apurinic (AP) sites, which are then converted to DNA single-strand breaks (SSBs) through an incision step, mediated by AP endonuclease 1 (Demple and Sung 2005)