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ET accumulates in skin cells and not only prevents oxidative damage but also facilitates DNA repair in UV-irradiated cells (80)

We demonstrated that BPC-157 significantly improved the wound healing activity on alkali-burned rats

In addition, PKC regulates the expression of a variety of cytokines and growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor- (TGF-) (Tanase et al., 2022), which are involved in pathological processes such as dysfunction of glomerular endothelial cells and proliferation of thylakoid cells, and increased synthesis of extracellular matrix during the development of DKD

Elevated levels may develop because of dehydration, intense exercise, uterine problems, or prostate issues

Through literature review, it is speculated that in animal models of neurodegenerative diseases, depletion of long-term nuclear receptor-assisted activator (NCOA4) in the brain can worsen the neurodegenerative disease phenotype due to the further inappropriate accumulation of free iron and resulted in oxidative stress (Quiles Del Rey and Mancias, 2019), and then induced ferroptosis in nerve cells
