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CDK4 and CDK6 are important CDKs members that regulated the transition from G1 to S phase and bind to Cyclin Ds (D1, D2 and D3) to form CDK4/6-Cyclin complex after being activated by mitotic signals, while the over-activated CDK4/6 destabilizes the genome and chromosome, leading to uncontrolled proliferation and ultimately abnormal cell cycle regulation [44]

Gewartowska, S

[DOI] [PMC free article] [PubMed] [Google Scholar] 170.Bello CE

LTC 4 synthase (a membranous GST) found in hematopoietic cells synthesizes LTC 4 (LTA 4 -GSH adduct), which is a precursor of cysteinyl-leukotrienes
Barrett E, Ross RP, OToole PW, Fitzgerald GF, Stanton C

Chen JX, Yan SD
