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Whole-brain radiation therapy, once a standard for patients ineligible for surgical resection or stereotactic radiosurgery (SRS), is now being reevaluated owing to its impact on cognitive function

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This re-directs glycolytic intermediates into the pentose phosphate- (PPP) and serine-pathways

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The MAPKK kinase family members identified to date include Raf, Mos, and Tpl

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