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Moreover, elevated systemic concentrations of TMAO enhanced thrombosis potential in vivo in animal models (4), and in recent clinical intervention studies, elevation in plasma TMAO induced with dietary choline supplementation altered platelet hyperresponsiveness in subjects (omnivores and vegans/vegetarians alike), as monitored by platelet aggregometry (17)

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Omnivores and vegans/vegetarians ingested deuterium-labeled l-carnitine (d 3 -l-carnitine) or BB (d 9 -BB), and both plasma metabolites and fecal polymicrobial transformations were examined at baseline, following oral antibiotics, or following chronic (2 months) l-carnitine supplementation

This can be particularly beneficial for individuals on weight loss programs