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After adding AuNP-MUA to the stirring mPEG- d -PEI solution, the deposition of mPEG- d -PEI onto the surface of the AuNP was performed for 30 min in the presence of 10 mM NaCl

Because the major site of action for metformin is the liver its use can be contraindicated in patients with liver dysfunction

Similarly, Salacia chinensis bark extract, administered intraperitoneally at 5 mg/kg daily for 2 weeks in SCC xenograft-bearing mice, inhibited tumor growth by 54% and decreased proliferation marker Ki-67 expression, while sparing normal tissue architecture ( Syngeneic and Orthotopic Models: Orthotopic implantation of mouse oral cancer cells into immunocompetent mice offers tumor microenvironment fidelity and immune system engagement (Tinajero-Diaz et al., 2021

The TRIB3 is induced in DR under ERS, leading to overexpression of HIF1

DKD accounts for 30%50% of all chronic kidney disease (CKD) cases, affecting 285 million patients worldwide ( As the prevalence of diabetes increases, so does the prevalence of DKD

Ravandi F, Faderl S, Cortes J, Garcia-Manero G, Jabbour E, Boone P, Kadia T, Borthakur G , Wierda W, Wetzler M, Venugopal P, Chiao J, Kantarjian H