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Description
PMC 1594586
A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington's disease mice
Pitolisant's efficacy could be mediated through its activity that increases the synthesis and release of histamine in the brain via competitive binding to presynaptic histamine-3 autoreceptors
Studies have shown impaired antioxidant functions connected to the onset and progression of numerous diseases 5
[DOI] [PubMed] [Google Scholar] 39.Balon TW
Pappano, W
