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The combination of declining estrogen, changing androgen ratios, and the metabolic stress of weight loss creates a perfect storm for follicular disruption

Not caused or worsened by semaglutide

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Small populations of vascular smooth muscle cells (VSMCs) already present in the intima proliferate in response to growth factors produced by inflammatory macrophages (136)

Zhu BQ, Zhou HZ, Teerlink JR, et al

In particular, they identified several proteins that were glutathionylated in patients with MS during a relapse, including three proteins (ECSOD, A1AT, and PLTP) which were oxidized at functionally important positions in their structure (Srivastava et al., 2019)