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Evidence on the mode of action of metformin shows that it improves insulin sensitivity by increasing insulin receptor tyrosine kinase activity and enhancing glycogen synthesis in hepatocytes, and by increasing recruitment and transport of GLUT4 transporters to the plasma membrane in adipose tissue

Firstly, there is a growing demand for natural and sustainable metabolites in todays society, and the production of plant bioactive metabolites from renewable resources has a lower environmental impact than metabolites that may involve harmful chemicals and processes ( 2 Skin aging Intrinsic/extrinsic factors play an important role in the skin aging process (Figure 1)

However, with the imbalance, the free radicals have access to different cells, causing deleterious effects on all biomolecules (Ivanov et al

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doi: 10.1007/s00217-020-03435-w

Effect of antioxidant, malondialdehyde, macro-mineral, and trace element serum concentrations in Bangladeshi patients with schizophrenia: a case-control study
