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1 ALS is an intractable, progressive, neurodegenerative disease that results in severe muscle atrophy and weakness in the muscles due to motor neuron dysfunction

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doi: 10.1152/ajpregu.00213.2004

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Transcription of hepcidin in response to increased plasmatic or tissue iron is mediated by Bone Morphogenetic Proteins (BMP) which requires hemojuvelin (HJV) as a coreceptor, and is SMAD-dependent
