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However, its clinical application has been limited by dose-dependent gastrointestinal toxicity observed in later phase I and II clinical trials
Emerging evidence also implicates gutbrain axis dysfunction and microbiome dysbiosis in PD, where peripheral synuclein pathology and intestinal inflammation may propagate neurodegeneration via vagal pathways [26]
Storage & Handling: Store lyophilized peptide at -20C
PNC-27 was not shown to have any significant effects on cell viability of normal murine lymphocytes, however, the peptide was capable of selectively targeting human leukemia cells without affecting normal lymphoid control cells
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The TPH1 gene encodes the predominant tryptophan hydroxylase responsible for serotonin synthesis in enterochromaffin cells of the intestines
