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American journal of obstetrics and gynecology 184, 12781283 (2001)

Exposure to cold weather can be life-threatening

After analyzing blood and tumor samples that had been collected over time from some participants, one finding of particular interest was that treatment with atezolizumab could "convert" tumors from those that initially lacked one of two proteins, PD-1 or PD-L1, needed for atezolizumab to work, to those that eventually produced high levels of either protein

G.OrluS.LiuJ.et al (2005)

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Actin Upregulation and Cellular Motility: TB-500 binds directly to actin, a major component of the cellular cytoskeleton