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In the SENTINEL study, 1171 patients who had experienced one or more relapses during the prior year of treatment with interferon beta-1a once weekly (30 mcg intramuscularly) were randomized to receive natalizumab (300 mg intravenously) or placebo every 4 weeks for 28 months (while continuing interferon beta-1a 30 mcg once-weekly treatment)

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Subsequently a large series of tetrazole derivatives were prepared and examined ( 41 , that is a competitive inhibitor of IRAP and exhibits an IC50 of 540 nM in a recombinant human IRAP assay