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Pure structural issues like severe disc extrusions or spinal stenosis show much more limited response

cerevisiae strains led to the conclusion that out-crossing occurs only about once every 50,000 cell divisions

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Local versus systemic administration (e.g., injecting near an injury site versus distant systemic injection) has been compared in several studies, with both approaches showing efficacy, suggesting the peptide works through systemic signalling pathways rather than purely local mechanisms