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However, the main concern for topical therapies is whether adequate drug concentrations could be accomplished at the targeted site ( In recent years, electromotive drug administration (EMDA) as a new delivery approach was developed to increase the concentration of drugs into specific tissues ( Potential Novel Drugs of PD As mentioned above, the phenotype transformation of fibroblast to myofibroblast in tunica albuginea has an important role in the pathogenesis of PD

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Structural changes such as cardiomyopathy, cardiac hypertrophy, interstitial cardiac fibrosis, endothelial dysfunction, and contractile protein failure can result from elevated oxidative stress in cardiac tissue (Emran et al

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