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This pathway is of particular relevance to disease as oxidative stress is a hallmark of many cancers, neurodegenerative disease, and more

doi: 10.1179/135100004225004742

Although most of the early experiments using cuprizone were conducted in mice, a number of studies demonstrated detrimental effects of cuprizone administration to the brain similar to those in mice of other rodents, such as rats [3135], guinea pigs [31] or hamsters [36, 37]

FP: Conceptualization, Data curation, Supervision, Writing original draft, Writing review & editing

Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors

In the physiological state, it is localized in the cell cytosol and is regulated by a variety of protein translational modifications (PTMs) to adapt to different cellular environments, such as phosphorylation, ubiquitination, S-nitrosylation, palmitoylation, and SUMOylation (Jin et al., 2021)