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Glutathione synthase (GSS) functions in glutathione (GSH) biosynthesis to protect cells from oxidative damage 33

PMID: 31801061 Anal Chem High-Throughput Reactive Desorption Electrospray Ionization Mass Spectrometry for Targeted Derivatization and Analysis of Poorly Ionized Small Molecules

Thus, we determined ER-stress response genes Xbp1 and the ER chaperone heat shock 70 kDa protein 5 (HSPA5, previously known as immunoglobulin heavy chain binding protein [BIP]), inflammation-responsive genes IL6 and IL1, and hypoxia-responsive genes hypoxia-inducible transcription factor 1 (HIF1) and GAPDH

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Overall, approximately 68% of patients receiving chemotherapy develop CIPN within the first month of treatment (Seretny et al., 2014), the development of which is related to both single as well as cumulative drug doses