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Intestinal epithelial cells establish a continuous monolayer through TJs, which comprise transmembrane proteins (e.g., occludin), claudin family proteins (e.g., claudin-1), and cytoplasmic scaffolding proteins (e.g., ZO-1, ZO-2, ZO-3).[13]

Formulation alternatives may provide relief: Different tablet formulations with alternative inactive ingredients may be better tolerated Liquid preparations can be easier to tolerate and allow flexible dosing Intramuscular injections completely avoid the gastrointestinal tract and are particularly useful for those with absorption issues (such as pernicious anaemia or malabsorption) or persistent oral intolerance Review inactive ingredients: Examine the supplement label for potential irritants or allergens

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BPC-157 shows promising results for lower back pain, particularly when inflammation and soft tissue damage are primary contributors

[DOI] [PMC free article] [PubMed] [Google Scholar] 97.De Palma C., Clementi E

Gut inflammation triggers brain inflammation through systemic immune signaling