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It's crucial to highlight that exceeding the recommended dosage does not necessarily translate to enhanced efficacy and may increase the likelihood of encountering adverse effects

While rodent modelsparticularly those avoiding confounding physiological effects of high systemic chemotherapy doseshave provided valuable insight, validation of the mechanisms of CIPN in patients has been difficult not least because of the extensive co-morbidities usually present in this patient group

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[DOI] [PMC free article] [PubMed] [Google Scholar] 170

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