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The effects of ginsenosides on PI3K/Akt signaling pathway

MGO has also been reported to induce autophagic pathways [60] which may act as a protective mechanism in BMECs to maintain BBB integrity [77]

1 Introduction Neurological diseases are multifactorial disorders caused by intrinsic and extrinsic factors, such as genetics, epigenetics, age and environmental factors, which result in cognitive dysfunction and behavioral disorders ( Epigenetic mechanisms, such as DNA methylation, non-coding RNA regulation, and histone modifications, are involved in these processes ( In the context of neural development, DNA methylation has emerged as a crucial mechanism in regulation of neural stem cell proliferation, synaptic plasticity, and neuronal repair ( 2 DNA methylation DNA methylation is catalyzed by DNA methyltransferases (DNMTs) with the transferring a methyl group to the cytosine ring within both CpG and non-CpG dinucleotides (32)

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doi: 10.3390/cells10112828 127 Leon-JuarezMMartinez-CastilloMGonzalez-GarciaLDHelguera-RepettoACZaga-ClavellinaVGarcia-CorderoJet al

Gallo at the NIH in early 1984 and that of Jay Levy in San Francisco, confirmed and extended our findings