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doi: 10.3389/ftubr.2025.1608780 Received 09 April 2025 Accepted 23 June 2025 Published 12 August 2025 Volume 3 - 2025 Edited by Novel N

To preserve and stabilize enzymes in formulation, technologies have been developed, among them encapsulation using liposome or nanoemulsion, addition of sugar or polyol as cosolute strengthening the hydration shell around the enzyme, or precise pH control matching the isoelectric point ensuring structural stability [193, 194]

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Published in Pharmaceuticals (PMID: 38675421), this 41-page open-access review proposes that BPC-157, while not meeting classical neurotransmitter criteria, functions as a cytoprotection mediator with neurotransmitter-like activity through a network of interconnected evidence. What Makes BPC-157 Unique BPC-157 is a 15-amino acid peptide (sequence: GEPPPGKPADDAGLV, molecular weight 1419) native and stable in human gastric juice for over 24 hours, showing no sequence homology with known gut peptides

[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Xia S, Yan L, Xu W, Agrawal AS, Algaissi A, Tseng CT, Wang Q, Du L, Tan W, Wilson IA, Jiang S