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At least in part, it was the practical fact of proximity

Rutaecarpine may improve neuronal injury, inhibits apoptosis, inflammation and oxidative stress by regulating the expression of ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia-reperfusion injury

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We therefore conclude that gp34 1-179 impairs proliferation, plasmablast differentiation, and subsequent immunoglobulin secretion in IgM + and IgA + B cells by reprogramming IgG + B cells