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These failures may be traced to the use of inappropriate biomarkers as guides to treatment development

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Moreover, we identified a previously unrecognized anti-tumor mechanism whereby disulfiram, an aldehyde dehydrogenase (ALDH) inhibitor, synergistically inhibited mitochondrial function when combined with NAMPT inhibitors - leading to cell cycle arrest in G2/M

doi: 10.1016/j.phrs.2021.105985 89 GaoNMaBJiaHHaoCJinTLiuX

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