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Appendix 2 Table of excluded reviews Appendix 3 Results of meta-analyses in the systematic reviews Appendix 4 Results of meta-analyses subgroup and sensitivity analyses Appendix 5 Results of RCTs fulfilling inclusion criteria Intention-to-treat values are reported where possible

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The study also evaluates the toxicity of berberine on zebrafish, and points out that long-term and excessive consumption of berberine may cause cardiac and hepatic toxicity

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