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doi: 10.1210/me.2007-0079

some individuals report sleep disturbances Foods and Substances to Avoid Around Dosing To optimize AOD-9604s effectiveness, avoid the following in the hour before and 30-60 minutes after administration: All foods (proteins, carbohydrates, fats trigger insulin response) Caloric beverages including juice, milk, sports drinks, protein shakes Artificial sweeteners (may trigger minor insulin response in some individuals) Coffee with cream or sugar (black coffee or tea without additives is acceptable) Acceptable During Dosing Window: Water, black coffee, unsweetened tea, electrolyte water (zero-calorie), and medications as prescribed

This offers a more convenient option for patients who prefer to avoid injections, while still supporting metabolic pathways under medical guidance

To determine the effect of NNMT inhibitor on NNMT activity in the pre-adipocytes and differentiated adipocytes (810 4 cells/well seeded prior to beginning differentiation), cells were treated with 30 M inhibitor for 24 h