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Lyophilized (Unopened): Store at 20 C (4 F) or below (ideally 80 C for multiyear storage) in a dry, dark environment [6]

Clinical studies have shown increased kynurenine concentrations and higher kynurenine/tryptophan ratios in colonic and ileal lesions of patients with IBD compared to those in healthy controls, probably due to increased IDO1 expression [62, 63]

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Additional formulations, including Qingre Xiaozheng Formula and Tang-Shen-Fang, have demonstrated the ability to rebalance microbial ecosystems, suppress metabolic inflammation, and reduce the production of gut-derived uremic toxins, thereby conferring renoprotective effects (229, 230)

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