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For MS/MS analysis, the mass spectra of fragments were recorded with a Bruker Ultraflex MALDI-TOF mass spectrometer in tandem mode (TOFTOF) with detection of positive ions
Exosomes, small vesicles produced by various cells, are essential for cellular communication and transporting molecules like proteins and nucleic acids

In colorectal cancer, IGF-2 secreted by cancer-associated fibroblasts binds to IGF-1R on cancer cells to activate the PI3K/AKT/mTOR and Hippo-YAP1 signaling pathways to promote cancer cell proliferation, migration and invasion

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PPARalpha and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia

However, challenges like bioavailability, off-target effects, TME heterogeneity, and metabolic plasticity persist
