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Mechanistically, the risk is attributed to the pharmacokinetic impact of piperine, which inhibits CYP3A4 and disrupts glucuronidation, increasing systemic curcumin exposure by over 20-fold and potentially converting otherwise safe doses into hepatotoxic levels in susceptible individuals

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It also intersects with compounding policy, where the FDA has been explicit that compounded products are not FDA-approved and cannot be marketed as if they are

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[DOI] [PubMed] [Google Scholar] 46.Pistone G., Marino A., Leotta C., DellArte S., Finocchiaro G., Malaguarnera M

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