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After 24 h, survival percentage, biochemical and morphological markers of liver injury, and tissue inflammation were assessed

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Besides that, PD-1 blockade also activates AMPK and mTOR, which in turn upregulates the expression of peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1 (PGC-1), resulting in increased mitochondrial activity together with ablation of PD-1, which suppresses tumor growth [66]

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