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Impaired clearance might also derive from disrupted peripheral A transport, as suggested by the sleep deprivation-induced downregulation of low-density lipoprotein receptor-related protein-1 (LRP-1), which promotes A efflux from the brain to the peripheral circulation across the BBB, and elevations of receptor of advanced glycation end products (RAGE), which promotes on the contrary the influx of peripheral A into the brain, thus preventing A clearance 149

doi: 10.1002/0471140864.ps1919s55

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Other studies have reported correlations between genotype and activity (157, 301) or between selenium and GPx-1 activity (285, 355)

, Alsugoor, M

[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Mokra D., Adamcakova J., Mokry J