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Current evidencethough limited and largely derived from studies in postmenopausal womensuggests beneficial effects on bone metabolism and systemic inflammation, particularly in osteoporosis

[DOI] [PMC free article] [PubMed] [Google Scholar] 219.Terzi EM, Sviderskiy VO, Alvarez SW, Whiten GC, Possemato R

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Higher intracellular MTX-PGs were associated with improved clinical responses and inter-individual variations in MTX-PG levels were shown to be at least partly (20%) explained by age, baseline erythrocyte-folate, a single nucleotide polymorphism in the gene for folylpolyglutamate synthetase, and MTX dose [41]

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