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Such a requirement of GSH for yeast viability has prevented evaluating its contribution to thiolredox control, and constitutes an enigma as to its molecular cause

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710 Cuproptosis represents a metal-dependent RCD defined in 2022, in which intracellular copper binds to lipoylated tricarboxylic-acid (TCA) cycle enzymes, most notably dihydrolipoamide S-acetyltransferase (DLAT), driving protein oligomerisation/aggregation, loss of FeS-cluster proteins, and mitochondrial proteotoxic stress in cells reliant on oxidative phosphorylation

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Topical wolverine stack application would likely provide only superficial wound healing benefits at the application site without the broader systemic effects that make this stack valuable

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[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Hariharan S., Dharmaraj S

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